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1

Double-prodrugs of L-cysteine: Differential protection against acetaminophen-induced hepatotoxicity in mice

Daune L. Crankshaw, Lorelle I. Berkeley, Jonathan F. Cohen, Frances N. Shirota, Herbert T. Nagasawa

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2002

Language:

english

File:

PDF, 150 KB

english, 2002

2

2-Substituted thiazolidine-4(R)-carboxylic acids as prodrugs of L-cysteine. Protection of mice against acetaminophen hepatotoxicity

Nagasawa, Herbert T., Goon, David J. W., Muldoon, William P., Zera, Richard T.

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 869 KB

english, 1984

3

Prodrugs of L-cysteine as protective agents against acetaminophen-induced hepatotoxicity. 2-(Polyhydroxyalkyl)- and 2-(polyacetoxyalkyl)thiazolidine-4(R)-carboxylic acids

Roberts, Jeanette C., Nagasawa, Herbert T., Zera, Richard T., Fricke, Robert F., Goon, David J. W.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 880 KB

english, 1987

4

Additions and Corrections-2-Substituted Thiazolidine-4(R)-carboxylic Acids as Prodrugs of L-Cysteine. Protection of Mice Against Acetaminophen Hepatotoxicity

Nagasawa, Herbert, Goon, David, Muldoon, William, Zera, Richard

Journal:

Journal of Medicinal Chemistry

Year:

1984

Language:

english

File:

PDF, 148 KB

english, 1984

5

Latent Alkyl Isocyanates as Inhibitors of Aldehyde Dehydrogenase in vivo

Nagasawa, Herbert T., Elberling, James A., Goon, David J. W., Shirota, Frances N.

Journal:

Journal of Medicinal Chemistry

Year:

1994

Language:

english

File:

PDF, 1.09 MB

english, 1994

6

Sequestration and Elimination of Toxic Aldehydes

Nagasawa, Herbert T., Valentekovich, Robert J., Nagasawa, Scott G., Nagasawa, Richard H.

Journal:

Chemical Research in Toxicology

Year:

2020

File:

PDF, 837 KB

2020

7

Protection against acetaminophen-induced hepatotoxicity by L-CySSME and its N-acetyl and ethyl ester derivatives

Herbert T. Nagasawa, Don W. Shoeman, Jonathan F. Cohen, William B. Rathbun

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

1996

Language:

english

File:

PDF, 102 KB

english, 1996

8

Differentiation of α- from γ-glutamyl dipeptides by chemical ionization mass spectrometry

Herbert T. Nagasawa, Sanne D. J. Magnan, Rodger L. Foltz

Journal:

Biological Mass Spectrometry = Journal of Mass Spectrometry (Wiley)

Year:

1982

Language:

english

File:

PDF, 428 KB

english, 1982

9

The Structure of “ITCA”, a Urinary Metabolite of Cyanide.

Herbert T. Nagasawa, Steven E. Cummings, Steven I. Baskin

Journal:

Year:

2004

File:

PDF, 66 KB

2004

10

Hepatoprotection by L-cysteine-glutathione mixed disulfide, a sulfhydryl-modified prodrug of glutathione

Lorelle I. Berkeley, Jonathan F. Cohen, Daune L. Crankshaw, Frances N. Shirota, Herbert T. Nagasawa

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2003

Language:

english

File:

PDF, 56 KB

english, 2003

11

p-Aminophenol-induced hepatotoxicity in hamsters: Role of glutathione

Xin Fu, Theresa S. Chen, Mukunda B. Ray, Herbert T. Nagasawa, Walter M. Williams

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2004

Language:

english

File:

PDF, 239 KB

english, 2004

12

Diverse antioxidants protect against acetaminophen hepatotoxicity

Helieh S. Oz, Craig J. McClain, Herbert T. Nagasawa, Mukunda B. Ray, Willem JS. de Villiers, Theresa S. Chen

Journal:

Journal of Biochemical and Molecular Toxicology

Year:

2005

Language:

english

File:

PDF, 193 KB

english, 2005

13

Synthesis of [14C]-pargyline {N-methyl-N-([1-14C]-propargyl)benzylamine} with the radioactive label on the propargyl group

David J. W. Goon, James A. Elberling, E. G. Demaster, Herbert T. Nagasawa

Journal:

Journal of Labelled Compounds and Radiopharmaceuticals

Year:

1990

Language:

english

File:

PDF, 245 KB

english, 1990

14

Latentiated forms of the transport-inhibitory α-amino acid adamantanine

Herbert T. Nagasawa, James A. Elberling, Frances N. Shirota

Journal:

Journal of Pharmaceutical Sciences

Year:

1980

Language:

english

File:

PDF, 509 KB

english, 1980

15

N-acetyl-DL-penicillamine and acetaminophen toxicity in mice

Richard T. Zera, Herbert T. Nagasawa

Journal:

Journal of Pharmaceutical Sciences

Year:

1980

Language:

english

File:

PDF, 247 KB

english, 1980

16

The antiviral drug amantadine has a direct inhibitory effect on T-lymphocytes

Connie Clark, Mildred M. Woodson, Vern B. Winge, Herbert T. Nagasawa

Journal:

Immunopharmacology

Year:

1989

Language:

english

File:

PDF, 778 KB

english, 1989

17

Inhibition of lymphocyte proliferation by amantadine and its isomer, 2-aminoadamantane; impact on Lyt-2+ T cells while sparing L3T4+ cells

Connie Clark, Mildred M. Woodson, Herbert T. Nagasawa

Journal:

Immunopharmacology

Year:

1991

Language:

english

File:

PDF, 794 KB

english, 1991

18

Mechanism for the inhibition of aldehyde dehydrogenase by nitric oxide

Eugene G. DeMaster, Beth Redfern, Barry J. Quast, Todd Dahlseid, Herbert T. Nagasawa

Journal:

Year:

1997

Language:

english

File:

PDF, 892 KB

english, 1997

19

Reaction of Nitroxyl, an Aldehyde Dehydrogenase Inhibitor, with N-Acetyl-L-Cysteine

Don W. Shoeman, Frances N. Shirota, Eugene G. DeMaster, Herbert T. Nagasawa

Journal:

Year:

2000

Language:

english

File:

PDF, 168 KB

english, 2000

20

Analysis of hepatic reduced glutathine, cysteine and homocysteine by cation-exchange high-performance liquid chromatography with electrochemical detection

Eugene G. Demaster, Frances N. Shirota, Beth Redfern, David J.W. Goon, Herbert T. Nagasawa

Journal:

Journal of Chromatography B: Biomedical Sciences and Applications

Year:

1984

Language:

english

File:

PDF, 511 KB

english, 1984

21

Prodrugs of L-cysteine as liver-protective agents. 2(R,S)-methylthiazolidine-4(R)-carboxylic acid (MTCA), a latent cysteine

Nagasawa, Herbert T., Goon, David J. D., Zera, Richard T., Yuzon, Daniel L.

Journal:

Journal of Medicinal Chemistry

Year:

1982

Language:

english

File:

PDF, 393 KB

english, 1982

22

Acyl, N-protected .alpha.-aminoacyl, and peptidyl derivatives as prodrug forms of the alcohol deterrent agent cyanamide

Kwon, Chul Hoon, Nagasawa, Herbert T., DeMaster, Eugene G., Shirota, Frances N.

Journal:

Journal of Medicinal Chemistry

Year:

1986

Language:

english

File:

PDF, 1.24 MB

english, 1986

23

Pargyline-induced hepatotoxicity: Possible mediation by the reactive metabolite, propiolaldehyde

Eugene G. DeMaster, Hatton W. Sumner, Eli Kaplan, Frances N. Shirota, Herbert T. Nagasawa

Journal:

Toxicology and Applied Pharmacology

Year:

1982

Language:

english

File:

PDF, 5.17 MB

english, 1982

24

Sulfanegen sodium treatment in a rabbit model of sub-lethal cyanide toxicity

Matthew Brenner, Jae G. Kim, Jangwoen Lee, Sari B. Mahon, Daniel Lemor, Rebecca Ahdout, Gerry R. Boss, William Blackledge, Lauren Jann, Herbert T. Nagasawa, Steven E. Patterson

Journal:

Toxicology and Applied Pharmacology

Year:

2010

Language:

english

File:

PDF, 758 KB

english, 2010

25

Effects of 2(RS)-n-propylthiazolidine-4(R)-carboxylic acid on extrahepatic sulfhydryl levels in mice treated with acetaminophen☆

Chandrika Srinivasan, Walter M Williams, Herbert T Nagasawa, Theresa S Chen

Journal:

Biochemical Pharmacology

Year:

2001

Language:

english

File:

PDF, 442 KB

english, 2001

26

Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues

Norman E Sládek, Ganaganur K Rekha, Melinda J.C Lee, Herbert T Nagasawa

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 208 KB

english, 2001

27

Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues

Norman E. Sládek, Ganaganur K. Rekha, Melinda J.C. Lee, Herbert T. Nagasawa

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 355 KB

english, 2001

28

Erratum to “Inhibition of ALDH3A1-catalyzed oxidation by chlorpropamide analogues” [Chem. Biol. Interact. 130–132 (2001) 135–149]

Norman E. Sládek, Ganaganur K. Rekha, Melinda J.C. Lee, Herbert T. Nagasawa

Journal:

Chemico-Biological Interactions

Year:

2001

Language:

english

File:

PDF, 34 KB

english, 2001

29

Glutathione monoethyl ester protects against glutathione deficiencies due to aging and acetaminophen in mice

Theresa S Chen, John P Richie Jr., Herbert T Nagasawa, Calvin A Lang

Journal:

Mechanisms of Ageing and Development

Year:

2000

Language:

english

File:

PDF, 238 KB

english, 2000

30

Protection Against Acetaminophen Hepatotoxicity by Ribose-Cysteine (RibCys)

Jeanette C. Roberts, Rajeev L. Charyulu, Richard T. Zera, Herbert T. Nagasawa

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

1992

Language:

english

File:

PDF, 486 KB

english, 1992

31

.beta.-Substituted cysteines as sequestering agents for ethanol-derived acetaldehyde in vivo

Nagasawa, Herbert T., Elberling, James A., Roberts, Jeanette C.

Journal:

Journal of Medicinal Chemistry

Year:

1987

Language:

english

File:

PDF, 852 KB

english, 1987

32

Prodrugs of nitroxyl as inhibitors of aldehyde dehydrogenase

Lee, Melinda J. C., Nagasawa, Herbert T., Elberling, James A., DeMaster, Eugene G.

Journal:

Journal of Medicinal Chemistry

Year:

1992

Language:

english

File:

PDF, 529 KB

english, 1992

33

Prevention of Naphthalene-Induced Cataract and Hepatic Glutathione Loss by theL-Cysteine Prodrugs, MTCA and PTCA

WILLIAM B. RATHBUN, HERBERT T. NAGASAWA, CHRISTINA E. KILLEN

Journal:

Experimental Eye Research

Year:

1996

Language:

english

File:

PDF, 332 KB

english, 1996

34

The Reaction of Nitroxyl (HNO) with Nitrosobenzene Gives Cupferron (N-Nitrosophenylhydroxylamine)

Don W. Shoeman, Herbert T. Nagasawa

Journal:

Year:

1998

Language:

english

File:

PDF, 107 KB

english, 1998

35

N-Hydroxybenzenecarboximidic Acid Derivatives: A New Class of Nitroxyl-Generating Prodrugs

Melinda J.C. Lee, Don W. Shoeman, David J.W. Goon, Herbert T. Nagasawa

Journal:

Year:

2001

Language:

english

File:

PDF, 116 KB

english, 2001

36

Generation of Nitric Oxide and Possibly Nitroxyl by Nitrosation of Sulfohydroxamic Acids and Hydroxamic Acids

Frances N. Shirota, Eugene G. DeMaster, Melinda J.C. Lee, Herbert T. Nagasawa

Journal:

Year:

1999

Language:

english

File:

PDF, 114 KB

english, 1999

37

Cardiotoxicity of alcohol

Carl S. Alexander, Herbert T. Nagasawa

Journal:

American Heart Journal

Year:

1974

Language:

english

File:

PDF, 138 KB

english, 1974

38

The metabolic activation of cyanamide to an inhibitor of aldehyde dehydrogenase is catalyzed by catalase

Eugene C. DeMaster, Frances N. Shirota, Herbert T. Nagasawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1984

Language:

english

File:

PDF, 523 KB

english, 1984

39

N,O-Diacylated-N-hydroxyarylsulfonamides: Nitroxyl precursors with potent smooth muscle relaxant properties

Jon M. Fukuto, Raina Hszieh, Priya Gulati, Kenneth T. Chiang, Herbert T. Nagasawa

Journal:

Biochemical and Biophysical Research Communications

Year:

1992

Language:

english

File:

PDF, 470 KB

english, 1992

40

Studies on the cyanamide-ethanol interaction: Dimethylcyanamide as an inhibitor of aldehyde dehydrogenase in vivo

Frances N. Shirota, Eugene G. Demaster, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1982

Language:

english

File:

PDF, 773 KB

english, 1982

41

Role of propiolaldehyde and other metabolites in the pargyline inhibition of rat liver aldehyde dehydrogenase

Eugene G. Demaster, Frances N. Shirota, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 1.09 MB

english, 1986

42

Prodrugs of cyanamide as (long-acting) alcohol deterrent agents

Herbert T. Nagasawa, Kwon Chul-Hoon, Eugene G. DeMaster, Frances N. Shirota

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 310 KB

english, 1986

43

Differential inhibition of rat tissue catalase by cyanamide

Eugene G. DeMaster, Beth Redfern, Frances N. Shirota, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1986

Language:

english

File:

PDF, 359 KB

english, 1986

44

Failure of glutathione and cysteine prodrugs to block the chlorpropamide-induced inhibition of aldehyde dehydrogenase in vivo

Frances N. Shirota, James A. Elberling, Herbert T. Nagasawa, Eugene G. DeMaster

Journal:

Biochemical Pharmacology

Year:

1992

Language:

english

File:

PDF, 374 KB

english, 1992

45

Nitroxyl analogs as inhibitors of aldehyde dehydrogenase: C-nitroso compounds

Herbert T. Nagasawa, Yul Yost, James A. Elberling, Frances N. Shirota, Eugene G. Demaster

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 591 KB

english, 1993

46

Metabolic activation of n-butyraldoxime by rat liver microsomal cytochrome P450: A requirement for the inhibition of aldehyde dehydrogenase

Eugene G. DeMaster, Beth Redfern, Frances N. Shirota, Daune L. Crankshaw, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1993

Language:

english

File:

PDF, 806 KB

english, 1993

47

Redistribution and enhanced urinary excretion of 2,2′,4,4′,5,5′-hexachlorobiphenyl (HCB) in rats using hcb-specific IgG and Fab fragments

Dan E. Keyler, David J.W. Goon, Weilin L. Shelver, Ccathy A. Ross, Herbert T. Nagasawa, John V.St. Peter, Paul R. Pentel

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 881 KB

english, 1994

48

Involvement of nitroxyl (HNO) in the cyanamide-induced vasorelaxation of rabbit aorta

Jon M. Fukuto, Priya Gulati, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1994

Language:

english

File:

PDF, 279 KB

english, 1994

49

Nitrosyl cyanide, a putative metabolic oxidation product of the alcohol-deterrent agent cyanamide

Frances N. Shirota, David J.W. Goon, Eugene G. DeMaster, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 714 KB

english, 1996

50

Maintenance of hepatic glutathione homeostasis and prevention of acetaminophen-induced cataract in mice by L-cysteine prodrugs

William B. Rathbun, Christina E. Killen, Ann M. Holleschau, Herbert T. Nagasawa

Journal:

Biochemical Pharmacology

Year:

1996

Language:

english

File:

PDF, 641 KB

english, 1996

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